Mesothelioma Survival Rate

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It is very sad to say that the survival rate of mesothelioma is very low. Statistics shows that In large case series, life expectancy is between 6-17 months, with an average of 12 months or less. The most important prognostic factors in mesothelioma are histological type, patient’s performance status and weight loss.

Positive Effects of Prognostic

  • Young age,
  • Absence of weight loss,
  • Absence of visceral pleural involvement,
  • Absence of chest pain,
  • Female gender.

Negative Effects of Prognostic

  • Advanced age,
  • Unknown fever,
  • Chest pain,
  • Shortness of breathing.

Prognostic factors in malignant pleural mesothelioma

Good prognostic factors Poor prognostic factors
Epithelial histology Sarcomatous or mixed histology
Less weight loss Excess weight loss
Age < 55 Age > 65
No chest pain Thrombocytosis

In malignant pleural mesothelioma, the researchs shows that no any treatments are curative. It is accepted that no single treatment option prolongs the life time and the most commonly used approach is trimodality treatment. Multiple treatment are used in early stage of the mesothelioma. Properly selected patients had satisfactory results with surgery, adjuvant chemotherapy and postoperative radiotherapy

Survival rate in patients receiving trimodality treatment

Below table shows some median survival rates of mesothelioma patients who had trimodality treatment

Number of PatientsTreatment MethodMedian Survival (months)
183– Extrapleural Pneumonectomy
– Radiotherapy
– Chemotherapy
19
62 – Extrapleural Pneumonectomy
– High Dose Radiotheraphy
34
74 – Extrapleural Pneumonectomy
– Radiotherapy
– Chemotherapy
17
45 – Chemotherapy
– Extrapleural Pneumonectomy
– Radiotherapy
23
208 – Extrapleural Pneumonectomy
– Radiotherapy
– Chemotherapy
20
17 – Chemotherapy
– Extrapleural Pneumonectomy
– High Dose Radiotherapy
26
50 – Extrapleural Pneumonectomy
– Radiotherapy
11
100– Extrapleural Pneumonectomy
– Intensity Modulated Radiotherapy
10
22– Extrapleural Pneumonectomy
– High Dose Radiotherapy
– Chemotherapy
19

Other Factors

In addition to age, type of mesothelioma, gender there are other factors affecting the survival rates of mesothelioma are listed below:

  • Location:  Peritoneal and pleural mesothelioma has the highest survial rates and Pericardial mesothelioma has the lowest survival rates.
  • Mesothelioma Type: Epithelioid mesothelioma generally has the highest survival rates, followed by biphasic mesothelioma and sarcomatoid mesothelioma.
  • Smooking Factors:  Smoking have lower survival rates than non-smokers as any other cancer types and diseases.

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